Validating therapeutically active phytochemical compounds for anti-ageing by in silico pharmacokinetic approach


Abstract:
The atmosphere is filled with UV radiations from the sun and pollutants. Everyone in the atmosphere is exposed to radiation and pollution that leads to various kinds of diseases. The main organ affected in our body is skin. Skin is the protective organ in our body. When the body is exposed to radiation, our skin gets affected and may lead to skin diseases, skin cancer and premature skin ageing. Skin ageing is a natural process; when the skin is affected by UV radiation, premature ageing occurs. It is important to prevent and protect the skin from photo ageing. Anti-oxidants play an important role in preventing skin ageing. Anti-oxidants are commonly present in our body, but they could not be able to prevent the free radicals that enter into the body; therefore, they do not balance oxidants and anti-oxidants. Hence, anti-oxidants are given exogenously to our body as a part of diet. Although most of the phytochemicals possess anti-oxidant property, knowing which compound is most active in the body is essential by validating the compounds through pharmacokinetics approach. Thirteen phytochemical compounds with anti-oxidant property were taken from the literature studies. The pharmacokinetic properties, such as absorption, distribution, metabolism and excretion of the drug in our body were studied using MOLINSPIRATION and SIMULATION PLUS software. The active compounds were found based upon the compounds' obedience to those pharmacokinetic properties. The compounds that obeyed the pharmacokinetic properties were found to be salicylic acid, cinnamic aldehyde and resveratrol. Of all these compounds, resveratrol has little toxic effects.

Keywords:
Anti-ageing; Pharmacokinetics; Skin ageing; ADMET validation; Phytochemicals risk factors

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How to cite this article:
Baskar V, Jayalakshmi C, Pavithra N, Veronica Grite S. Validating therapeutically active phytochemical compounds for anti-ageing by in silico pharmacokinetic approach. Journal of Biological and Information Sciences. 2014. 3 (1). 1-7.
Available from: http://ojournals.biolim.com/BOJ001/001/BOJ001A0024.