Polymer coated magnetic nanoparticles mediated delivery of anti-Alzheimer drug and their characterisation


Abstract:

Alzheimer's disease is an irreversible, progressive brain disorder that occurs because of the changes in the nerve cells that result in the death of brain cells. Several drugs are available for Alzheimer's disease, but those drugs come with side effects and very less bio-availability. New therapeutic and diagnostic concepts of several areas of medicine are recently developing in the field of nanotechnology even to address the problem of patients with Alzheimer's to reduce the dosage and site directed therapy. Hence, it is possible to deliver the drugs through magnetic nanoparticles to reduce the side effects and increase the bio-availability with the help of nanotechnology. Magnetic nanoparticles exhibit some toxicity to the cells. For reducing the toxic effect of magnetic nanoparticles, several measures were taken by coating with biocompatible polymers. Magnetic nanoparticles were prepared by co-precipitation method and coated with poly-vinyl alcohol. They were characterised by Zeta potential, TEM and FTIR analysis. The antibacterial activity and haemolysis were checked for determining the toxicity level. MTT assay of coated and uncoated magnetic nanoparticles were also performed in A459 human lung cancer to determine their cytotoxicity level. Finally, in vitro drug release kinetics was checked for anti-Alzheimer's drug by dialysis method. The coated magnetic nanoparticles were characterised with TEM as they have shown size of around 342.0 nm and their Zeta size and potential also prominently proved their average size and charge distribution as 342.0 nm and -1.74 mV. There was no antibacterial activity for polymer coated magnetic nanoparticles. Haemolysis activity of magnetic nanoparticles had shown less toxicity to the cells. MTT assay had shown that, the cell tolerability can be made up to 10 mg to reduce the cell growth of A549 cells. Anti-Alzheimer's drug was loaded in polymer coated magnetic nanoparticles and finally checked for in vitro drug release kinetics. This new method provides a solution for the side effects, which are common in normal drug delivery modes. The drug here works on the application of drug to the targeted site, and the bio-availability of the drug can also be increased by this way.



Keywords:
Bio-availability; Polymer coated magnetic nanoparticles; Anti-Alzheimer drug; Targeted drug delivery

Full text PDF | Download PDF



How to cite this article:
Banu S, Thamarai RS, Zunaidha Farzana S, Baskar V. Polymer coated magnetic nanoparticles mediated delivery of anti-Alzheimer drug and their characterisation. Journal of Biological and Information Sciences. 2013. 2 (3). 21-27.
Available from: http://ojournals.biolim.com/BOJ001/001/BOJ001A0021.